Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1211 | Obesity | ICEECE2012

ASP injection promotes macrophage infiltration and M1 polarization in obese adipose tissue

Fisette A. , Oikonomopoulou K. , Munkonda M. , Lambris J. , Cianflone K.

Recent integrative approaches showed that adipose tissue play a major endocrine role. Molecules secreted by the expanding adipose tissue modulate systemic inflammation and contribute heavily to the pathology of obesity co-morbidities. Acylation stimulating protein (ASP) is an adipokine that has been linked with energy metabolism and lipid metabolism. The ASP receptor, C5L2, is widespread within tissues in the organism, yet ASP effects outside the adipose tissue remain explored...